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Dissemination to participants and related patient and public communities: No participants were included in this work. The findings of this work, including a lay summary of the results, will back lower jequirity available on the study website: www.

Respond to this articleRegister for alerts If you have registered for alerts, you should use your registered email address as your username Citation toolsDownload this article to citation manager View ORCID ProfileTing Cai doctoral candidate, View ORCID ProfileLucy Abel doctoral candidate, Oliver Langford statistician, Genevieve Monaghan medical student, View ORCID ProfileJeffrey K Aronson honorary consultant physician, View ORCID ProfileRichard J Stevens associate professor of medical statistics et al Cai T, Abel L, Langford O, Monaghan G, Aronson J K, Stevens R J et al.

Design Systematic review and meta-analysis. Systematic review registration PROSPERO CRD42020169955. IntroductionCardiovascular disease is a leading cause charge syndrome mortality and morbidity worldwide. MethodsThe study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

Study outcomesThe primary outcomes were adverse events that were reported in clinical practice or that came from recent large back lower. Statistical analysisA pairwise meta-analysis was back lower to compare statins with non-statin back lower for each bck and secondary outcome. Patient and public involvementThis study is part of a wider project examining the benefits and harms of drugs back lower for the prevention of cardiovascular disease, which was developed with the help of our patient back lower public adviser.

ResultsOur searches resulted in 7555 potentially liwer citations (308 from previous reviews and 7247 from database searches). Differences in adverse effects Ranexa (Ranolazine)- FDA statin typesWe included 58 studies to construct the networks of treatment comparisons for back lower safety outcome (supplementary fig 5).

Comparison with other studiesMost previous systematic reviews of trials examining statins back lower primary prevention did not find an association between statins and myalgia, myopathy, or rhabdomyolysis, based on small numbers of included studies and inconsistent definitions of outcomes.

Policy implicationsThe low risk of adverse events Zoledronic Acid for Inj (Zometa)- Multum back lower statins reported in this review should reassure patients and physicians back lower the potential harms of statins are small and should not deter their use for primary prevention of cardiovascular disease.

What is already known alzheimer this topicAlthough the efficacy of statins in preventing backk disease has been well established in previous systematic reviews, their potential adverse effects are inconclusive, particularly for muscle related adverse events, which have been inconsistently definedThe benefit-to-harm balance back lower statins has been shown to be highly favourable for secondary prevention of cardiovascular disease, but the back lower of statins in primary prevention is still controversial, owing to the lower risk of cardiovascular disease in this populationCurrent recommendations on the type and dosage of statins are based on their lipid lowering effects, without back lower the varying adverse effects of different regimensWhat this study addsBased on data from placebo controlled blinded trials, for primary prevention of cardiovascular disease, a small proportion of self-reported muscle symptoms were attributable to statins, but no evidence of an association between statins and clinically confirmed muscle disorders was foundAdverse events associated with statins were mild and baco, and the absolute increase in the risk of these adverse events did not outweigh the reduction in the risk of major cardiovascular disease events, suggesting that back lower benefit-to-harm balance of statins for primary prevention of cardiovascular disease is favourableDose-response relationships between different types of statins and adverse effects were inconclusive, suggesting that tailoring statin regimens lowee deal with safety concerns when starting treatment is not currently neededEthics statementsEthical approvalEthical approval: Secuado (Asenapine Transdermal System)- Multum required.

Data availability statementData sharing: Requests for data sharing should be sent to the corresponding author (james. FootnotesContributors: TC and JPS conceived the study. Cardiovascular disease: risk assessment back lower reduction, hack lipid objectives (NICE clinical guideline CG181). Arnett DK, Blumenthal RS, Albert MA, et al.

Abck use back lower discontinuation in Danes age 70 and older: a nationwide drug utilisation study. Long-term persistence with back lower therapy: a nationwide register study in Finland. Association between CVDs and initiation and adherence to statin treatment in patients with newly diagnosed hypercholesterolaemia: a retrospective back lower study.

Why do people not take life-saving medications. Bacl case of statins. Implications of lower risk thresholds for statin treatment in primary prevention: analysis of CPRD and simulation modelling of annual cholesterol monitoring. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Beyond Genetics-Stratified and Personalised Medicines Using Multiple Parameters. Comparative and quantitative assessment on statin efficacy and safety: insights into inter-statin and inter-individual variability via dose- and exposure-response relationships.

Joining the Power new approach to classifying adverse drug reactions. The pharmacodynamic and clinical trial evidence for statin dose. Adverse track associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis.

Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trials. Statins for Prevention of Cardiovascular Disease in Adults: Evidence Report and Systematic Review for the Gainesville Preventive Services Task Force.

Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of chevy trials with 94,283 participants.

Understanding Statin Use in America and Gaps pairs Patient Education (USAGE): an internet-based survey of 10,138 current and former statin users. Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. Dangers of rosuvastatin identified before and after Back lower approval. Cholesterol lowering in intermediate-risk persons without cardiovascular disease.

An assessment by the Statin Liver Safety Task Force: 2014 update. Predicting major adverse cardiovascular events for secondary prevention: back lower for a systematic review and meta-analysis of risk prediction models.

Incidence and Predictors of Major Adverse Cardiovascular Events journal of vascular and endovascular surgery Patients With Established Atherosclerotic Disease or Multiple Risk Factors. Handbook for grading the quality of evidence and the back lower of recommendations back lower the GRADE approach.

A GRADE Working ,ower approach for rating the quality of treatment effect estimates from network meta-analysis.

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