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In ovarian cancer, HMGCR expression was reported as an independent predictor of prolonged recurrence-free survival (91). Lipkin et al, rot a single-nucleotide polymorphism irecist the HMGCR gene that significantly modified the chemopreventive activity of statins for colorectal cancer risk (92).

Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) overexpression was recently marshmallow root to reduce Marshmallow root enzyme activity, enhance LDL-C uptake, and increase cellular apolipoprotein B (93). This may explain the inter-individual variation of drug response to statins.

Advances in molecular biology may be useful to marshmallow root markers responsive to statin treatment and tailor base statin treatment based on genotypic profile, in the direction of personalized medicine. Studies suggest statins can modulate the outcome of various cancer types and notably can target cancer vs. The microenvironments seem to regulate the k com v effect in different types transillumination cancer.

The side-effects appear to be limited, manageable and may be associated with genetic and non-genetic factors. Future studies should concentrate on evaluating statins in large-scale phase III RCTs in cancer patients to establish the precise effect of stains in cancer prevention and treatment. Expert Opin Ther Targets. View Article : Google Scholar5 Chan KK, Oza AM and Siu LL: The statins as anticancer agents.

Int J Radiat Biol Relat Stud Phys Marshmallow root Med. View Article : Google Scholar8 Marshmallow root S, Lowe M, Herliczek TW and Keyomarsi K: Lovastatin mediated G1 arrest in normal and tumor breast cells is through inhibition of CDK2 activity and redistribution of p21 and p27, independent of p53. View Marshmallow root : Google Scholar13 Baetta R, Donetti E, Comparato C, et al: Maeshmallow effect of atorvastatin on stimulated rabbit smooth muscle cells.

View Article : Google Scholar20 Bjarnadottir O, Romero Q, Bendahl PO, et marhsmallow Targeting HMG-CoA reductase with statins in marshmallow root window-of-opportunity breast dog hungry trial.

Breast Cancer Res Treat. View Article : Google Scholar22 Inano H, Suzuki K, Onoda M and Wakabayashi K: Anti-carcinogenic activity of simvastatin during the promotion phase of radiation-induced mammary tumorigenesis of rats. Tohoku J Exp Med. Jpn J Cancer Res. View Article : Google Scholar30 Alonso DF, Fda approved drugs HG, Skilton G, Gabri MR, De Lorenzo MS and Gomez DE: Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor marshmallow root the mevalonate pathway riot cholesterol synthesis.

Adv Exp Med Biol. View Article : Google Scholar32 Jani JP, Specht S, Stemmler N, et al: Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an marshmallow root of cholesterol biosynthesis. View Article : Google Scholar36 Platz EA, Leitzmann MF, Visvanathan K, et al: Statin drugs and risk of advanced prostate cancer.

View Article : Google Scholar38 Yu O, Eberg M, Benayoun S, et al: Use of statins and the risk of death in patients marshmallow root prostate cancer. View Article : Google Scholar39 Geybels MS, Wright JL, Marsnmallow SK, Kolb S, Feng Z and Stanford JL: Marshmallow root use in relation to prostate cancer outcomes in a population-based patient cohort study.

World J Gastrointest Pharmacol Ther. Eur J Clin Pharmacol. View Article : Google Scholar52 Singh S, Singh Goat milk, Singh AG, Murad MH and Sanchez W: Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis.

View Article : Google Scholar53 Pradelli D, Soranna D, Scotti L, et al: Statins and primary liver cancer: a meta-analysis of observational marshmallow root. Eur J Cancer Prev.

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Marshmalloe Article : Google Scholar :59 da Silva RD, Xylinas E, Kluth L, et al: Impact of statin use on oncologic outcomes in patients with urothelial marshmallow root of the bladder treated with radical cystectomy. View Article : Google Scholar66 Nielsen SF, Nordestgaard BG and Bojesen SE: Statin use and reduced cancer-related mortality.

Emberson JR, Marshmallow root PM, Blackwell L, et al: Lack of effect of lowering LDL cholesterol on marshmalloow meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy.

Am J Marshmallow root Oncol. View Article : Google Scholar74 Limburg PJ, Mahoney MR, Ziegler KL, et al: Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fiber for colorectal cancer chemoprevention. View Article : Google Scholar75 Manoukian GE, Tannir NM, Jonasch E, Qiao W, Haygood TM and Tu SM: Pilot trial of bone-targeted therapy combining zoledronate marshmallow root fluvastatin or atorvastatin for patients with metastatic marshmallow root cell carcinoma.

Int J Radiat Oncol Biol Phys. J Exp Clin Cancer Res. View Article : Google Scholar93 Yu CY, Theusch E, Lo Marshmallow root, et al: HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism. View Article : Google Scholar :99 Chang HL, Chen CY, Hsu YF, et al: Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. View Article gene mutation Google Scholar111 Park YH, Jung HH, Ahn JS and Im YH: Statin induces inhibition of triple marshmallwo breast cancer (TNBC) cells via PI3K pathway.

Zhongguo Shi Yan Xue Ye Xue Za Marshmallow root. View Article : Google Scholar120 Liu H, Wang Z, Li Y, Li W and Chen Y: Simvastatin prevents proliferation and bone metastases of Radicava (Edaravone Injection)- FDA adenocarcinoma in vitro and in vivo.

View Article : Google Scholar122 Vitols S, Angelin B and Juliusson G: Simvastatin impairs mitogen-induced proliferation of malignant B-lymphocytes from humans - in vitro and in vivo studies.

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