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Tablets: 50 mg oval, light orange, scored, film-coated, with SEARLE and 1041 debossed on the scored side and ALDACTONE and 50 on the other side. Tablets: 100 mg round, peach-colored, vk vine, film-coated, vk vine SEARLE and 1031 debossed on the scored side and Vk vine and 100 on the other side. ALDACTONE can cause hyperkalemia. Monitor serum potassium within 1 week of initiation or titration of ALDACTONE and regularly thereafter. In addition to causing hyperkalemia, ALDACTONE can cause hyponatremia, hypomagnesemia, hypocalcemia, hypochloremic alkalosis, and hyperglycemia.

Asymptomatic hyperuricemia can occur and rarely gout is precipitated. Monitor serum electrolytes, uric acid and blood glucose periodically. ALDACTONE can cause gynecomastia. Gynecomastia is usually reversible. The following clinically significant adverse reactions are described elsewhere in the labeling:The following adverse reactions associated with the use of spironolactone were identified vk vine clinical trials or postmarketing reports. Because these reactions were reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency, reliably, vk vine to establish a causal relationship to drug exposure.

Digestive: Gastric bleeding, ulceration, gastritis, diarrhea vk vine cramping, nausea, vomiting. Reproductive: Vk vine libido, inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal vk vine, breast and nipple pain.

Hematologic: Leukopenia (including agranulocytosis), thrombocytopenia. Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic vk vine, vasculitis. Skin: Vk vine Syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS), alopecia, pruritis. Concomitant administration of ALDACTONE with potassium supplementation or drugs that can increase potassium may lead vk vine severe hyperkalemia.

Check serum potassium levels when ACE inhibitor or ARB therapy is altered in patients receiving ALDACTONE. Like other diuretics, ALDACTONE reduces the renal clearance of lithium, thus increasing the risk of lithium toxicity.

In some patients, the administration of an NSAID can reduce vk vine diuretic, natriuretic, and antihypertensive effect of diuretics. Spironolactone and its metabolites interfere with radioimmunoassays for digoxin and increase the apparent exposure to digoxin.

Clomid and is unknown to what extent, if any, spironolactone may increase actual digoxin exposure. In patients taking concomitant digoxin, use an assay that does not interact with spironolactone. Hyperkalemic metabolic acidosis has been reported in patients given ALDACTONE concurrently with cholestyramine. Acetylsalicylic acid may reduce the efficacy of spironolactone.

Based on mechanism of action and findings in animal studies, spironolactone vk vine affect vk vine differentiation of the male during embryogenesis (see Data).

Limited available data from published case reports and case series vk vine not demonstrate an association of major malformations or other adverse pregnancy outcomes with spironolactone. There are risks to the mother and fetus associated with heart failure, cirrhosis and poorly controlled hypertension during pregnancy (see Clinical Considerations). Because of the potential risk to the male fetus due to anti-androgenic properties of spironolactone and animal data, avoid spironolactone in pregnant women or advise a pregnant woman of the potential risk to a male fetus.

The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss or other vk vine outcomes. Pregnant women with congestive heart failure are at increased risk for preterm excercising. Stroke volume and heart rate increase during pregnancy, increasing cardiac output, vk vine during the first trimester.

Clinical classification of heart disease may worsen with pregnancy and lead to maternal death. Closely monitor pregnant patients for destabilization of their heart failure. Pregnant women with symptomatic cirrhosis generally have poor outcomes including hepatic failure, variceal hemorrhage, preterm delivery, fetal growth restriction and maternal death. Outcomes are worse with coexisting esophageal varices.

Pregnant women with cirrhosis of the liver should be carefully monitored and managed accordingly.

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Comments:

08.05.2019 in 12:29 rophliadersi:
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08.05.2019 in 18:46 caldofi:
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09.05.2019 in 14:40 Бронислав:
Не могу сейчас поучаствовать в обсуждении - нет свободного времени. Вернусь - обязательно выскажу своё мнение.

09.05.2019 in 17:55 Исай:
Верно! Идет!

14.05.2019 in 02:14 Эвелина:
Запись невозможна: диск переполнен (П)овтор, (Ф)ормат, (З)вонок #911?